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Bhosale, A. V.
- Chemo Informatics:Newer Approach for Drug Development
Abstract Views :174 |
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Authors
Affiliations
1 S.G.R.S College of Pharmacy, Saswad, Pune-413302, Maharashtra, IN
1 S.G.R.S College of Pharmacy, Saswad, Pune-413302, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 1-7Abstract
Chemo informatics is a scientific discipline that has evolved in the last 40 years at the interface between chemistry and computer science. It has been realized that in many areas of chemistry, the huge amount of data and information produced by chemical research can only be processed and analyzed by computer methods. Furthermore, many of the problems faced in chemistry are so complex that novel approaches utilizing solutions that are based on informatics methods are needed. Thus, methods were developed for building databases on chemical compounds and reactions, for the prediction of physical, chemical and biological properties of compounds and materials, for drug design, for structure elucidation, for the prediction of chemical reactions and for the design of organic syntheses.Keywords
Chemi Informatics, Drug Development, Structure Activity Relationship.- Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Dosage Form
Abstract Views :155 |
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Authors
V. P. Godse
1,
M. N. Deodhar
1,
A. V. Bhosale
1,
R. A. Sonawane
1,
P. S. Sakpal
1,
D. D. Borkar
1,
Y. S. Bafana
1
Affiliations
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 86-89Abstract
Two simple, sensitive accurate, precise, rapid and economical methods were developed for the estimation of Ezetimibe and Atorvastatin in two components solid dosage form. First method is based on simultaneous equations and second method is based on absorbance ratio method. Ezetimibe has absorbance maxima at 232.5 nm and Atorvastatin has Absorbance maxima at 246.5 nm in methanol. The linearity was obtained in the concentration range 5-30 mcg/ml for both Ezetimibe and Atorvastatin. In the first method the concentration of the drugs were determined by using simultaneous equations and in second method, concentration of the drugs were determined by using ratio of absorbance at iso-absorptive point and at λmax of one of the drug. The results of analysis have been validated statistically and by recovery studies.Keywords
Ezetimibe, Atorvastatin, Simultaneous Equations, Absorbance Ratio, Iso-Absorptive Point.- Reverse Phase HPLC Method for Determination of Aceclofenac and Paracetamol in Tablet Dosage Form
Abstract Views :170 |
PDF Views:0
Authors
V. P. Godse
1,
M. N. Deodhar
1,
A. V. Bhosale
1,
R. A. Sonawane
1,
P. S. Sakpal
1,
D. D. Borkar
1,
Y. S. Bafana
1
Affiliations
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN